The use of Human Exosomes in the practice of medicine

Rejuvenate the brain from the inside out with Stem Cell Therapy.

What is Neuro-Regenesis? The word “neuro” relates to nerves, and “genesis” refers to the formation of something. When we use the term Neuro-Regenesis we are implying re-forming or re-growth of neurons. This process is most active while a baby is developing in the womb and is responsible for the production of the brain’s neurons. As we age our ability to regenerate cells or neurons diminishes. Hundreds of millions of people worldwide are affected by neurological conditions such as Parkinson ’s disease, Stroke Recovery, Muscular Dystrophy, Multiple Sclerosis, dystonia, epilepsy, traumatic brain damage, as well as other conditions not mentioned here. Stem/progenitor cells and their bio-products, exosomes/extracellular vesicles (EV), offer a new promising treatment for damaged brains and rejuvenation for aging brains.

Stem cell-based therapies, including the mesenchymal stem cells (MSCs), have been used in clinics for more than 2 decades to treat neurological disorders. These cells are unspecialized cells that can differentiate and regenerate into various specialized cell types. The initial concept for using stem cells in treating the aging brain and neurological injury and diseases was aimed at re-growing parts of the brain, but evidence now shows that stem cells secrete extracellular vesicles (EV) exosomes that induce neuroprotection that can restore the brain’s capacity to reshape and neurologically recover and promote neuro-regeneration.

What are Mesenchymal stem cells?

Adult mesenchymal stem cells (MSC) exert their healing impact by donating mitochondria and exosomes to the progenitor cells in the tissue that they are directed to for regeneration. Exosomes offer an alternative advantage over MSC in the fact that they are stable in body fluids. Exosomes do not become trapped by the liver, lungs, and spleen during their journey through the body, and can freely cross the blood brain barrier to promote or stimulate “re-growth” of neurons.

What are Exosomes?

Exosome are membrane vesicles that are stored inside of the stem cells and are secreted when the exosome membrane fuses with the stem cell’s plasma membrane. Exosomes deliver bioactive molecules such as proteins, mRNAs, micro-RNAs, bioactive lipids, and signaling receptors.

Exosomes/extracellular vesicles (EV), used in our clinic are derived from healthy, medically screened females who have a planned C-section. The EV are then collected from amniotic fluid and cord-blood mesenchymal stem cells (MSC).

In 2018 Dr. Nebbeling went through training in Neuro-Regenesis with stem cells and exosomes. Dr. Nebbeling was supervised as he administered therapy to patients with Parkinson’s disease and Alzheimer’s, as well as patients with anti-aging issues. In 2019 Dr. Nebbeling will complete his training in PHRP (Protecting Human Research Participation) and then will be joining a formal multi-center IRB study for researching Neuro-Regenesis with exosomes.

Our office, Advanced Osteopathic Health, is excited to be involved in promoting the use of medically and ethically approved stems cells and exosomes to support our patients in their healing process in what we refer to as Neuto-Regenesis.

Our product is provided by the Center for Regenerative Medicine, Inc. The laboratory is located in the United States of America, and owned by an American MD physician and scientist. The laboratory is FDA registered and FDA compliant.

Each lot of human cells or tissue-based product provides samples from that lot that are sent off to several FDA registered laboratories for third party analysis. Dr. Nebbeling keeps certification of registration and analysis for stem cells used in our office.

You do not have to wait to join this protocol, Dr. Nebbeling’s office is scheduling appointments for evaluations today to see if you qualify for Neuro-Regenesis. Please feel free to call and schedule a consultation for this exciting breakthrough in medicine.

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